Wispack – An R package for warped sigmoidal Poisson-process mixed-effects modeling

Wispack (pronounced “wisp package” or “wisp pack”) is an R package for testing for between-group effects on spatial variation in spatial transcriptomics data. As such variation is often functional, these can be thought of as functional spatial effects (FSE).

See the GitHub repository for the package description, documentation, and tutorial.

And check out the preprint for more details on the method and its applications.

Artistic rendering of wisp model

Last Updated: Feb 19, 2026 by Michael Barkasi